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Miro1 Reducer

Catalog #: 7091 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7091/10
7091/50
Miro1 Reducer | CAS No. 2624336-91-8 | Miro1/Rhot1
1 Image
Description: Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

Chemical Name: N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride

Purity: ≥98%

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Biological Activity

Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Technical Data

M.Wt:
425.85
Formula:
C20H16FN7O.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2624336-91-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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