Mitochondrial fusion promoter M1

Biological Activity

Mitochondrial fusion promoter M1 is a mitochondrial fusion promoter. Protects cells from mitochondrial fragmentation-associated cell death. Induces mitochondrial fusion in effector T cells imposing a memory T cell morphology. Improves cellular respiration and potentiates glucose-stimulated insulin-secretion in cholesterol-exposed pancreatic β cells. Mitochondrial fusion promoter M1 also enhances mitochondrial dynamics and transport velocity in axons of the sciatic nerve in vitro and enhances axon regeneration in the optic nerve in an in vivo model of nerve damage.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Restoring mitochondrial function: a small molecule-mediated approach to enhance glucose stimulated insulin secretion in cholesterol accumulated pancreatic beta cells.
   Asalla et al.
   Sci.Rep., 2016;10:27513
2. A small molecule promotes mitochondrial fusion in mammalian cells.
   Wang et al.
   Angew.Chem.Int.Ed.Engl., 2012;51:9302
3. Mitochondrial dynamics controls T cell fate through metabolic programming.
   Buck et al.
   Cell, 2016;166:63

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