Mitoxantrone dihydrochloride

Tocris Bioscience | Catalog # 4250

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent
Tocris Bioscience
Discontinued Product
4250 has been discontinued. View all DNA Topoisomerase Inhibitors products.

Key Product Details

Description

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent
View all DNA Topoisomerase Inhibitors »

Product Description

Mitoxantrone dihydrochloride is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Product Specifications for Mitoxantrone dihydrochloride

Molecular Weight

517.40

Formula

C22H28N4O6.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

CAS Number

70476-82-3

PubChem ID

51082

InChI Key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

SMILES

O=C2C3=C(C(O)=CC=C3O)C(C1=C(NCCNCCO)C=CC(NCCNCCO)=C12)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.59 5
DMSO 38.8 75

Preparing Stock Solutions for Mitoxantrone dihydrochloride

The following data is based on the product molecular weight 517.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.58 mL 12.88 mL 25.77 mL
3.75 mM 0.52 mL 2.58 mL 5.15 mL
7.5 mM 0.26 mL 1.29 mL 2.58 mL
37.5 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for Mitoxantrone dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Mitoxantrone dihydrochloride

For research use only

⚠ WARNING: This product can expose you to chemicals including Mitoxantrone hydrochloride, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for Mitoxantrone dihydrochloride

Customer Reviews for Mitoxantrone dihydrochloride (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Mitoxantrone dihydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human epidermal carcinoma cell line
    Verified Customer | Posted 11/17/2019
    Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
    Mitoxantrone dihydrochloride 4250

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All