Mitoxantrone dihydrochloride

Catalog # Availability Size / Price Qty
4250/50
Mitoxantrone dihydrochloride | CAS No. 70476-82-3 | DNA Topoisomerase Inhibitors
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Description: Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent

Chemical Name: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Technical Data

M.Wt:
517.4
Formula:
C22H28N4O6.2HCl
Solubility:
Soluble to 5 mM in water and to 75 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
70476-82-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Mitoxantrone hydrochloride, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for Mitoxantrone dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Mitoxantrone dihydrochloride include:

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma
By Anonymous on 11/17/2019
Species: Human

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.