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Mitoxantrone dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:4250
Chemical Name:1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
Type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.
Technical Data
  • M.Wt:
    517.4
  • Formula:
    C22H28N4O6.2HCl
  • Solubility:
    Soluble to 5 mM in water and to 75 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    70476-82-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mitoxantrone dihydrochloride include:

1 Citations: Showing 1 - 1

  1. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther  2017;16(6):1021

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