Mitoxantrone dihydrochloride
Chemical Name: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Purity: ≥98%
Biological Activity
Mitoxantrone dihydrochloride is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival.
Burkhart et al.
Mol.Cancer Res., 2013;11:901 -
Mitoxantrone: a review of its uses in multiple sclerosis.
Scott and Figgit
CNS Drugs., 2004;18:379 -
Mitoxantrone affects topoisomerase activities in human breast cancer cells.
Crespi et al.
Biochem.Biophys.Res.Comm., 1986;136:521 -
A new target for an old drug: identifying mitoxan. as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.
Wan et al.
J.Med.Chem., 2013;56:2619
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Citations for Mitoxantrone dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Mitoxantrone dihydrochloride include:
2 Citations: Showing 1 - 2
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The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Authors: Zhang
Mol Cancer Ther 2017;16(6):1021
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The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Oncotarget 2015;6:510
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Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
