MK6-83

Key Product Details

Product Description

MK6-83 is a TRPML channel activator (EC₅₀ = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC₅₀ values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Product Specifications for MK6-83

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MK6-83

The following data is based on the product molecular weight 336.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.86 mL	29.72 mL
5 mM	0.59 mL	2.97 mL	5.94 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Chen A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 2014 PMID: 25119295

Product Documents for MK6-83