MK6-83

Catalog # Availability Size / Price Qty
5547/10
5547/50
Cat.No. 5547 - MK6-83 | C16H20N2O2S2 | CAS No. 1062271-24-2
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Description: TRPML channel activator

Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Technical Data

M.Wt:
336.47
Formula:
C16H20N2O2S2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1062271-24-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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