MKT 077

Catalog # Availability Size / Price Qty
MKT 077 | CAS No. 147366-41-4 | HSP70 Modulators
1 Image
Description: Binds mot-2; selectively cytotoxic in cancer cells

Chemical Name: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

MKT 077 is an occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

Technical Data

Soluble to 50 mM in water and to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for MKT 077

The citations listed below are publications that use Tocris products. Selected citations for MKT 077 include:

1 Citation: Showing 1 - 1

  1. Hsp70 and DNAJA2 limit CFTR levels through degradation.
    Authors: Chiaw Et al.
    PLoS One  2019;14:e0220984


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