MKT 077

Key Product Details

Product Description

MKT 077 is an occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

Product Specifications for MKT 077

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MKT 077

The following data is based on the product molecular weight 432.00.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.63 mL	23.15 mL	46.30 mL
2.5 mM	0.93 mL	4.63 mL	9.26 mL
5 mM	0.46 mL	2.31 mL	4.63 mL
25 mM	0.09 mL	0.46 mL	0.93 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Patury Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 2009 PMID: 19860737
• Wadhwa Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 2002 PMID: 12154051
• Tikoo Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 1999 PMID: 10526670
• Wadhwa Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 2000 PMID: 11156371

Product Documents for MKT 077