Chemical Name: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
Biological ActivityOccupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445.
Tikoo et al.
Cancer J.Sci.Am., 1999;5:293
Pharmacological targeting of the Hsp70 chaperone.
Patury et al.
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.
Wadhwa et al.
Cancer Res., 2000;60:6818
Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo.
Wadhwa et al.
Cancer Res., 2002;62:4434
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