Chemical Name: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
Biological ActivityOccupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.
Wadhwa et al.
Cancer Res., 2000;60:6818
Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo.
Wadhwa et al.
Cancer Res., 2002;62:4434
Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445.
Tikoo et al.
Cancer J.Sci.Am., 1999;5:293
Pharmacological targeting of the Hsp70 chaperone.
Patury et al.
Citation for MKT 077
The citations listed below are publications that use Tocris products. Selected citations for MKT 077 include:
1 Citation: Showing 1 - 1
Hsp70 and DNAJA2 limit CFTR levels through degradation.
Authors: Chiaw Et al.
PLoS One 2019;14:e0220984
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