ML 00253764 hydrochloride

Catalog # Availability Size / Price Qty
4854/10
4854/50
ML 00253764 hydrochloride | CAS No. 1706524-94-8 | Melanocortin Receptor Antagonists
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Description: Melanocortin MC4 receptor antagonist; brain penetrant

Chemical Name: 2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride

Purity: ≥98%

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Biological Activity

Non-peptide, melanocortin MC4 receptor antagonist (IC50 values are 320, 810 and 2120 nM for MC4, MC3 and MC5 receptors respectively). Decreases cAMP accumulation in HEK-293 cells expressing the MC4 receptor. Increases food intake and reduces loss of lean body mass in tumor bearing mice. Brain penetrant.

Technical Data

M.Wt:
413.71
Formula:
C18H18BrFN2O.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1706524-94-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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