Catalog Number: 4549
Chemical Name: N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
Biological Activity
Selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).
Technical Data
  • M.Wt:
    313.82
  • Formula:
    C19H19NO.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1222781-70-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133.
    Wang et al.
    ACS Chem.Biol., 2011;6:845
  2. A potent and selective small molecule Kir2.1 inhibitor.
    Wu et al.
    Probe Reports from the NIH Molecular Libraries Pro, 2010;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 133 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states.
    Authors: Lam and Schlichter
    Nat Commun 2015;9:185

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