ML 133 hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:4549
Chemical Name:N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
Product Details
Citations (2)
Reviews
Biological Activity
Selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).
Technical Data
  • M.Wt:
    313.82
  • Formula:
    C19H19NO.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    1222781-70-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 133 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia.
    Authors: Siddiqui Et al.
    J Neuroinflammation  2016;13:66
  2. Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states.
    Authors: Lam and Schlichter
    Nat Commun  2015;9:185

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