ML 133 hydrochloride

Tocris Bioscience | Catalog # 4549

Kir2 channel blocker
Tocris Bioscience

Key Product Details

Description

Kir2 channel blocker
View all Inward Rectifier Potassium Channel Blockers »

Product Description

ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).

Product Specifications for ML 133 hydrochloride

Molecular Weight

313.82

Formula

C19H19NO.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride

CAS Number

1222781-70-5

PubChem ID

44247466

InChI Key

NGQIBUUFXDPHKT-UHFFFAOYSA-N

SMILES

COC(C=C3)=CC=C3CNCC1=C(C=CC=C2)C2=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.38 100

Preparing Stock Solutions for ML 133 hydrochloride

The following data is based on the product molecular weight 313.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.87 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for ML 133 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 133 hydrochloride

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for ML 133 hydrochloride

Customer Reviews for ML 133 hydrochloride (1)

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  • ML 133 hydrochloride was used on Calcium-activated 6T & 1P potassium channels
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/27/2019
    ML 133 hydrochloride was used on Calcium-activated 6T & 1P potassium channels. The product works ideally on cell culture labs and would highly recommend.
    ML 133 hydrochloride 4549

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