Selective blocker of inwardly rectifying Kir
2 potassium channels (IC50
values are 1.8, 2.8, 2.9 and 4.0 μ
M at pH 7.4 for mKir
2.2 and hKir
2.3 respectively). Exhibits no effect on rKir
> 300 μ
M); displays weak activity at hKir
7.1 and rKir
values are 33 and 76 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133.
Wang et al.
ACS Chem.Biol., 2011;6:845
A potent and selective small molecule Kir2.1 inhibitor.
Wu et al.
Probe Reports from the NIH Molecular Libraries Pro, 2010;
The citations listed below are publications that use Tocris products. Selected citations for ML 133 hydrochloride include:
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