Catalog Number: 4266
Alternate Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Biological Activity
Allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A potent and selective inhibitor of Cdc42 GTPase.
    Surviladze et al.
    Probe Reports from the Molecular Libraries Program, 2010;:NBK5196
  2. Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe.
    Hong et al.
    J.Biol.Chem., 2013;:Epub
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