Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Biological ActivityML 141 is an allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe.
Hong et al.
A potent and selective inhibitor of Cdc42 GTPase.
Surviladze et al.
Probe Reports from the Molecular Libraries Program, 2010;:NBK5196
Citations for ML 141
The citations listed below are publications that use Tocris products. Selected citations for ML 141 include:
15 Citations: Showing 1 - 10
A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases.
Authors: Li Et al.
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.
Authors: Thottacherry Et al.
Nat Commun 2018;9:4217
Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells.
Authors: Pontremoli Et al.
Sci Rep 2018;8:16671
Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
Authors: Sepúlveda-Ramírez Et al.
Dev Biol 2018;437:140
FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
Authors: Hak Et al.
Nat Cell Biol 2018;20:1023
Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
Authors: Ford Et al.
PLoS Pathog 2018;14:e1007051
GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.
Authors: Xing Et al.
Mol Biol Cell 2016;27:3828
Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.
Authors: Najjar Et al.
PLoS Pathog 2016;12:e1005922
Dynasore disrupts trafficking of herpes simplex virus proteins.
Authors: Mues Et al.
J Virol 2015;89:6673
Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts.
Authors: Sumida and Yamada
J Biol Chem 2015;290:3238
Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization.
Authors: Lomakin Et al.
Nat Cell Biol 2015;17:1435
P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells.
Authors: El-Sayed Et al.
Nat Commun 2014;307:C83
Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.
Authors: McNary Et al.
Tissue Eng Part A 2014;20:921
Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts.
Authors: Wan Et al.
Biochem Biophys Res Commun 2013;433:502
Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior.
Authors: Tseng Et al.
Am J Physiol Cell Physiol 2012;9:1113
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