Allosteric inhibitor of Cdc42 GTPase (EC50
= 2.1 μ
M). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro
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A potent and selective inhibitor of Cdc42 GTPase.
Surviladze et al.
Probe Reports from the Molecular Libraries Program, 2010;:NBK5196
Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe.
Hong et al.
The citations listed below are publications that use Tocris products. Selected citations for ML 141 include:
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