ML 141

Catalog # Availability Size / Price Qty
4266/10
4266/50
ML 141 | CAS No. 71203-35-5 | Rho GTPase Inhibitors
1 Image
Description: Selective Cdc42 Rho family inhibitor
Alternative Names: CID 2950007

Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide

Purity: ≥99%

Product Details
Citations (15)
Reviews

Biological Activity

Allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Technical Data

M.Wt:
407.49
Formula:
C22H21N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
71203-35-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe.
    Hong et al.
    J.Biol.Chem., 2013;:Epub
  2. A potent and selective inhibitor of Cdc42 GTPase.
    Surviladze et al.
    Probe Reports from the Molecular Libraries Program, 2010;:NBK5196

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Citations for ML 141

The citations listed below are publications that use Tocris products. Selected citations for ML 141 include:

15 Citations: Showing 1 - 10

  1. A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases.
    Authors: Li Et al.
    iScience  2019;12:232
  2. Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.
    Authors: Thottacherry Et al.
    Nat Commun  2018;9:4217
  3. Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells.
    Authors: Pontremoli Et al.
    Sci Rep  2018;8:16671
  4. Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
    Authors: Sepúlveda-Ramírez Et al.
    Dev Biol  2018;437:140
  5. FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
    Authors: Hak Et al.
    Nat Cell Biol  2018;20:1023
  6. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
    Authors: Ford Et al.
    PLoS Pathog  2018;14:e1007051
  7. GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.
    Authors: Xing Et al.
    Mol Biol Cell  2016;27:3828
  8. Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.
    Authors: Najjar Et al.
    PLoS Pathog  2016;12:e1005922
  9. Dynasore disrupts trafficking of herpes simplex virus proteins.
    Authors: Mues Et al.
    J Virol  2015;89:6673
  10. Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts.
    Authors: Sumida and Yamada
    J Biol Chem  2015;290:3238

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