Catalog Number: 4266
Alternate Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Biological Activity
Allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.
Technical Data
  • M.Wt:
    407.49
  • Formula:
    C22H21N3O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    71203-35-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A potent and selective inhibitor of Cdc42 GTPase.
    Surviladze et al.
    Probe Reports from the Molecular Libraries Program, 2010;:NBK5196
  2. Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe.
    Hong et al.
    J.Biol.Chem., 2013;:Epub
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 141 include:

6 Citations: Showing 1 - 6
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  1. Dynasore disrupts trafficking of herpes simplex virus proteins.
    Authors: Mues Et al.
    J Virol 2015;89:6673
  2. Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts.
    Authors: Sumida and Yamada
    J Biol Chem 2015;290:3238
  3. P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells.
    Authors: El-Sayed Et al.
    Nat Commun 2014;307:C83
  4. Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.
    Authors: McNary Et al.
    Tissue Eng Part A 2014;20:921
  5. Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts.
    Authors: Wan Et al.
    Biochem Biophys Res Commun 2013;433:502
  6. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior.
    Authors: Tseng Et al.
    Am J Physiol Cell Physiol 2012;9:1113

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