Chemical Name: 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
Biological ActivityML 145 is a selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.
Jenkins et al.
Antagonists for the orphan receptor GPR35.
Heynen-Genel et al.
Probe Reports from the Molecular Libraries Program, 2010;:NBK5070
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VersaClone cDNA Plasmids
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