ML 145

Catalog # Availability Size / Price Qty
4172/10
4172/50
ML 145 | CAS No. 1164500-72-4 | Orphan 7-TM Receptor Antagonists
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Description: GPR35 antagonist

Chemical Name: 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid

Purity: ≥98%

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Biological Activity

Selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.

Technical Data

M.Wt:
482.57
Formula:
C24H22N2O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1164500-72-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.
    Jenkins et al.
    J.Pharmacol.Exp.Ther., 2012;343:683
  2. Antagonists for the orphan receptor GPR35.
    Heynen-Genel et al.
    Probe Reports from the Molecular Libraries Program, 2010;:NBK5070

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