ML 145

Key Product Details

Product Description

ML 145 is a selective antagonist for the GPR35 orphan receptor GPCR (IC₅₀ = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.

Product Specifications for ML 145

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 145

The following data is based on the product molecular weight 482.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.72 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Jenkins Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 2012 PMID: 22967846
• Heynen-Genel Antagonists for the orphan receptor GPR35. Probe Reports from the Molecular Libraries Program

Product Documents for ML 145