ML 162 New
Chemical Name: 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
Biological ActivityML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of small-molecule probes that selectively kill cells induced to express mutant RAS.
Weïwer et al.
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