ML 179

Catalog # Availability Size / Price Qty
4957/10
4957/50
Cat.No. 4957 - ML 179 | C21H25F3N4O2
1 Image
Description: Selective liver receptor homolog 1 (LRH1) inverse agonist

Chemical Name: 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione

Purity: ≥99%

Product Details
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Biological Activity

Selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Technical Data

M.Wt:
422.44
Formula:
C21H25F3N4O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2).
    Busby et al.
    Probe Reports from the NIH Molecular Libraries Program, 2010;

Product Datasheets

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