Catalog Number: 4957
Chemical Name: 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
Biological Activity
Selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.
Technical Data
  • M.Wt:
    422.44
  • Formula:
    C21H25F3N4O2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2).
    Busby et al.
    Probe Reports from the NIH Molecular Libraries Program, 2010;

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