Chemical Name: 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
Biological ActivityML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2).
Busby et al.
Probe Reports from the NIH Molecular Libraries Program, 2010;
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breast cancer cells line