ML 179

Tocris Bioscience | Catalog # 4957

Selective liver receptor homolog 1 (LRH1) inverse agonist
Tocris Bioscience

Key Product Details

Description

Selective liver receptor homolog 1 (LRH1) inverse agonist
View all Other Nuclear Receptors Inverse Agonists »

Product Description

ML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Product Specifications for ML 179

Molecular Weight

422.44

Formula

C21H25F3N4O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione

CAS Number

1883548-87-5

PubChem ID

45100448

InChI Key

MFABFKUNLDYKGH-UHFFFAOYSA-N

SMILES

O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 50

Preparing Stock Solutions for ML 179

The following data is based on the product molecular weight 422.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.73 mL 23.67 mL 47.34 mL
2.5 mM 0.95 mL 4.73 mL 9.47 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
25 mM 0.09 mL 0.47 mL 0.95 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 179

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 179

For research use only

Customer Reviews for ML 179 (1)

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  • Selective liver receptor homolog 1 (LRH1) inverse agonist
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: BT-474
    Verified Customer | Posted 11/16/2018
    Dilution buffer 100% DMSO for a stock solution at 10mM, used in a cell line where it showed a potent activity (breast cancer cells; IC50 values of 370nM).
    breast cancer cells line

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