Chemical Name: N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide
Biological ActivityML 190 is a selective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy.
Frankowski et al.
ACS Chem.Neurosci., 2012;3:221
Antagonist for the kappa opioid receptor.
Hedrick et al.
Probe Reports from the NIH Molecular Libraries Pro, 2011;
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