ML 190

Key Product Details

Product Description

ML 190 is a selective κ opioid receptor (KOP) antagonist (IC₅₀ = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.

Product Specifications for ML 190

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 190

The following data is based on the product molecular weight 488.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.23 mL	51.17 mL	102.34 mL
1 mM	2.05 mL	10.23 mL	20.47 mL
2 mM	1.02 mL	5.12 mL	10.23 mL
10 mM	0.20 mL	1.02 mL	2.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hedrick Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro 2011 PMID:  22091479
• Frankowski Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 2012 PMID: 22737280

Product Documents for ML 190