ML 190

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4866/10
4866/50
ML 190 | CAS No. 1355244-02-8 | Kappa Opioid Receptor Antagonists
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Description: Selective κ opioid receptor antagonist

Chemical Name: N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide

Purity: ≥98%

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Biological Activity

ML 190 is a selective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.

Technical Data

M.Wt:
488.58
Formula:
C27H32N6O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1355244-02-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy.
    Frankowski et al.
    ACS Chem.Neurosci., 2012;3:221
  2. Antagonist for the kappa opioid receptor.
    Hedrick et al.
    Probe Reports from the NIH Molecular Libraries Pro, 2011;

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