Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Biological ActivitySelective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Screening for selective ligands for GPR55 - antagonists.
Heynen-Genel et al.
Probe Reports from the NIH Molecular Libraries Program, 2010;
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
Kotsikorou et al.
Citation for ML 193
The citations listed below are publications that use Tocris products. Selected citations for ML 193 include:
1 Citation: Showing 1 - 1
Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner.
Biochem Biophys Res Commun 2017;489(2):243
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