ML 193

Catalog # Availability Size / Price Qty
ML 193 | CAS No. 713121-80-3 | GPR55 Receptor Antagonists
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Description: Potent, selective GPR55 antagonist
Alternative Names: CID 1261822

Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews (1)

Biological Activity

Selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Screening for selective ligands for GPR55 - antagonists.
    Heynen-Genel et al.
    Probe Reports from the NIH Molecular Libraries Program, 2010;
  2. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
    Kotsikorou et al.
    Biochemistry, 2013;52:9456

Product Datasheets

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Citations for ML 193

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ML-193 effect on microglia immunal function
By Anonymous on 09/21/2019
Species: Mouse

ML-193 was used to study the effect of receptor GPR-55 on release of prostaglandin E2 from hippocampal microglia. ML-193 triggered highly significant lowering of the prostaglandin release compared to control; however, difference between the effects of four tested doses was non-significant (see figure).

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