Catalog Number: 4860
Alternate Names: CID 1261822
Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Biological Activity
Selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Screening for selective ligands for GPR55 - antagonists.
    Heynen-Genel et al.
    Probe Reports from the NIH Molecular Libraries Program, 2010;
  2. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
    Kotsikorou et al.
    Biochemistry, 2013;52:9456
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