Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Biological ActivitySelective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Screening for selective ligands for GPR55 - antagonists.
Heynen-Genel et al.
Probe Reports from the NIH Molecular Libraries Program, 2010;
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
Kotsikorou et al.
Citations for ML 193
The citations listed below are publications that use Tocris products. Selected citations for ML 193 include:
3 Citations: Showing 1 - 3
Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
Authors: Alharris Et al.
Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells.
Authors: Saliba Et al.
J Neuroinflammation 2018;15:322
Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner.
Biochem Biophys Res Commun 2017;489(2):243
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ML-193 was used to study the effect of receptor GPR-55 on release of prostaglandin E2 from hippocampal microglia. ML-193 triggered highly significant lowering of the prostaglandin release compared to control; however, difference between the effects of four tested doses was non-significant (see figure).