Selective GPR55 antagonist (IC50
= 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1
, GPR35 and CB2
, respectively. Inhibits ERK signaling in vitro
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All Tocris products are intended for laboratory research use only.
Screening for selective ligands for GPR55 - antagonists.
Heynen-Genel et al.
Probe Reports from the NIH Molecular Libraries Program, 2010;
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
Kotsikorou et al.