ML 193

Catalog # Availability Size / Price Qty
4860/10
Cat.No. 4860 - ML 193 | C28H25N5O4S | CAS No. 713121-80-3
1 Image
Description: Potent, selective GPR55 antagonist
Alternative Names: CID 1261822

Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

Selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

Technical Data

M.Wt:
527.59
Formula:
C28H25N5O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
713121-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Screening for selective ligands for GPR55 - antagonists.
    Heynen-Genel et al.
    Probe Reports from the NIH Molecular Libraries Program, 2010;
  2. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
    Kotsikorou et al.
    Biochemistry, 2013;52:9456

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for ML 193

The citations listed below are publications that use Tocris products. Selected citations for ML 193 include:

1 Citation: Showing 1 - 1

  1. Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner.
    Authors: Drzazga
    Biochem Biophys Res Commun  2017;489(2):243

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for ML 193

There are currently no reviews for this product. Be the first to review ML 193 and earn rewards!

Have you used ML 193?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.