ML 193

Tocris Bioscience | Catalog # 4860

Potent, selective GPR55 antagonist
Tocris Bioscience

Key Product Details

Description

Potent, selective GPR55 antagonist

Alternative Names

CID 1261822
View all GPR55 Receptor Antagonists »

Product Description

ML 193 is a selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

Product Specifications for ML 193

Molecular Weight

527.59

Formula

C28H25N5O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

CAS Number

713121-80-3

PubChem ID

1261822

InChI Key

HTSLEZOTMYUPLU-UHFFFAOYSA-N

SMILES

CC2=CC(C)=CC1=C(C(NC4=CC=C(S(=O)(NC5=C(C)C(C)=NO5)=O)C=C4)=O)C=C(C3=CC=CC=N3)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.76 100

Preparing Stock Solutions for ML 193

The following data is based on the product molecular weight 527.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.90 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.90 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.90 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for ML 193

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 193

For research use only

Customer Reviews for ML 193 (1)

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  • ML-193 effect on microglia immunal function
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 09/21/2019
    Soluble in DMSO, perfectly mixes with artificial cerebro-spinal fluid.
    ML-193 was used to study the effect of receptor GPR-55 on release of prostaglandin E2 from hippocampal microglia. ML-193 triggered highly significant lowering of the prostaglandin release compared to control; however, difference between the effects of four tested doses was non-significant (see figure).
    ML 193 4860

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