ML 204

Key Product Details

Product Description

ML 204 is a blocker of TRPC4 channels (IC₅₀ values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Product Specifications for ML 204

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 204

The following data is based on the product molecular weight 226.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.42 mL	22.09 mL	44.19 mL
5 mM	0.88 mL	4.42 mL	8.84 mL
10 mM	0.44 mL	2.21 mL	4.42 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

• Miller Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 2011 PMID: 21795696
• Miller Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program 2011 PMID: 22049577

Product Documents for ML 204