ML 204

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ML 204 | CAS No. 5465-86-1 | TRPC Channel Blockers
1 Image
Description: Selective TRPC4 inhibitor

Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

ML 204 is a blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in 1eq. HCl with gentle warming
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel chemical inhibitor of TRPC4 channels.
    Miller et al.
    Probe Reports from the Molecular Libraries Program, 2011;
  2. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels.
    Miller et al.
    J.Biol.Chem., 2011;286:33436

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Citation for ML 204

The citations listed below are publications that use Tocris products. Selected citations for ML 204 include:

1 Citation: Showing 1 - 1


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