ML 204

Catalog # Availability Size / Price Qty
4732/10
4732/50
Cat.No. 4732 - ML 204 | C15H18N2 | CAS No. 5465-86-1
1 Image
Description: Selective TRPC4 blocker

Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline

Purity: ≥99%

Product Details
Reviews

Biological Activity

Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Technical Data

M.Wt:
226.32
Formula:
C15H18N2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in 1eq. HCl with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
5465-86-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Novel chemical inhibitor of TRPC4 channels.
    Miller et al.
    Probe Reports from the Molecular Libraries Program, 2011;
  2. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels.
    Miller et al.
    J.Biol.Chem., 2011;286:33436

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ML 204

There are currently no reviews for this product. Be the first to review ML 204 and earn rewards!

Have you used ML 204?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.