ML 210

Key Product Details

Product Description

ML 210 is a glutathione peroxidase (GPX4) inhibitor. Kills mutant RAS-expressing cell lines (IC₅₀ values are 71 and 272 nM for HRAS G12v mutant expressing cell lines BJeLR and BJeH-LT, respectively). Exhibits 4-fold selectivity for HRAS mutant-expressing cell lines. Induces ferroptosis in tumor initiation "persister" cells and drug-resistant tumor cells.

Product Specifications for ML 210

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 210

The following data is based on the product molecular weight 475.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.21 mL	21.04 mL	42.08 mL
2.5 mM	0.84 mL	4.21 mL	8.42 mL
5 mM	0.42 mL	2.10 mL	4.21 mL
25 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Yang Regulation of ferroptotic cancer cell death by GPX4. Cell 2014 PMID: 24439385
• Hangauer Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature 2017 PMID: 29088702
• Weïwer Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett. 2012 PMID: 22297109

Product Documents for ML 210