ML 213
Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
Purity: ≥99%
Biological Activity
Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine.
Vicente-Baz et al.
Neuropharmacology, 2016;109:131 -
Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener.
Yu et al.
ACS Chem.Neurosci., 2011;2:572
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Citations for ML 213
The citations listed below are publications that use Tocris products. Selected citations for ML 213 include:
2 Citations: Showing 1 - 2
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Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine.
Authors: Vincente-Baz Et al.
Neuropharmacology 2016;109:131
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Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.
Authors: Brueggemann Et al.
Mol.Pharmacol. 2014;86:330
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ML 213 was recently used to understand its effect on Kv11.1 and overall voltage gating mechanism. Different level of activation was observed.