ML 213

Catalog # Availability Size / Price Qty
4519/10
4519/50
ML 213 | CAS No. 489402-47-3 | Voltage-gated Potassium Channel Activators
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Description: KV7.2 and KV7.4 channel opener

Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.

Technical Data

M.Wt:
257.37
Formula:
C17H23NO
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
489402-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ML 213

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2 Citations: Showing 1 - 2

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ML 213 was used to study Kv11.1 channel activation
By Sadequl Islam on 11/07/2018
Application: Species: Human

ML 213 was recently used to understand its effect on Kv11.1 and overall voltage gating mechanism. Different level of activation was observed.


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