7.2 (KCNQ2) and KV
7.4 (KCNQ4) channel opener (EC50
values are 230 and 510 nM for KV
7.2 and KV
7.4 respectively). Displays > 80-fold selectivity against KV
7.3 and KV
7.5 in a thallium-based fluorescence assay.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener.
Yu et al.
ACS Chem.Neurosci., 2011;2:572
The citations listed below are publications that use Tocris products. Selected citations for ML 213 include:
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