ATP-competitive inhibitor of p97 ATPase (IC50
= 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
Soluble to 20 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.
Chou et al.