Catalog Number: 5153
Chemical Name: 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
Biological Activity
ATP-competitive inhibitor of p97 ATPase (IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.
    Chou et al.
    ChemMedChem, 2013;8:297
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