Catalog Number: 5625
Alternate Names: LH601A
Chemical Name: (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
Biological Activity
Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.
Technical Data
  • M.Wt:
    446.5
  • Formula:
    C26H26N2O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1432500-66-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Oxidative stress in Alzheimer's disease: are we connecting the dots?
    Rosini et al.
    J.Med.Chem., 2014;57:2821
  2. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.
    Hu et al.
    Bioorg.Med.Chem.Lett., 2013;23:3039
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