ML 334

Key Product Details

Product Description

ML 334 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (K_d = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.

Product Specifications for ML 334

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 334

The following data is based on the product molecular weight 446.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.20 mL	22.40 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Rosini Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 2014 PMID: 24131448
• Hu Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 2013 PMID: 23562243

Product Documents for ML 334