Chemical Name: N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide
Biological ActivitySelective K2P2.1 (TREK-1; KCNK2) and K2P10.1 (TREK-2; KCNK10) activator (EC50 values of 14.3 μM and 5.2 μM, respectively); directly stimulates the C-type gate via the K2P modulator pocket. Does not activate K2P4.1 (TRAAK).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Schewe et al.
Protein and chemical determinants of BL-1249 action and selectivity for K2P channels.
Pope et al.
ACS Chem.Neurosci., 2018;9:3153
Two-pore domain potassium channels: emerging targets for novel analgesic drugs: IUPHAR Review 26.
Gada et al.
K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Lolicato et al.
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