ML 351

Catalog # Availability Size / Price Qty
ML 351 | CAS No. 847163-28-4 | Lipoxygenase Inhibitors
1 Image
Description: Selective 12/15 LOX inhibitor; active in vivo

Chemical Name: 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile

Purity: ≥98%

Product Details

Biological Activity

ML 351 is a selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.
    Rai et al.
    J.Med.Chem., 2014;57:4035
  2. Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1.
    Rai et al.
    Probe Reports from the NIH Molecular Libraries Program, 2014;

Product Datasheets

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