ML 351

Key Product Details

Product Description

ML 351 is a selective 12/15 LOX inhibitor (IC₅₀ = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.

Product Specifications for ML 351

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 351

The following data is based on the product molecular weight 249.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.06 mL	40.12 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Rai Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program 2014 PMID: 24672829
• Rai Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J.Med.Chem. 2014 PMID: 24684213

Product Documents for ML 351