ML 351

Catalog # Availability Size / Price Qty
6448/25
6448/5
Cat.No. 6448 - ML 351 | C15H11N3O | CAS No. 847163-28-4
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Description: Selective 12/15 LOX inhibitor; active in vivo

Chemical Name: 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile

Purity: ≥98%

Product Details
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Biological Activity

Selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.

Technical Data

M.Wt:
249.27
Formula:
C15H11N3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
847163-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.
    Rai et al.
    J.Med.Chem., 2014;57:4035
  2. Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1.
    Rai et al.
    Probe Reports from the NIH Molecular Libraries Program, 2014;

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