Potent and selective TASK-1 (K2P
3.1/KCNK3) channel blocker (IC50
values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir
2.1, voltage-gated potassium channels, KCNQ2 and KV
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel.
Zou et al.
Probe Reports from the NIH Molecular Libraries Program, 2013;
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.
Flaherty et al.