ML 365

Tocris Bioscience | Catalog # 5337

Potent and selective K2P3.1 (TASK-1) channel blocker
Tocris Bioscience

Key Product Details

Description

Potent and selective K2P3.1 (TASK-1) channel blocker
View all Two-P Potassium Channels Blockers »

Product Description

ML 365 is a potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).

Product Specifications for ML 365

Molecular Weight

360.41

Formula

C22H20N2O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

CAS Number

947914-18-3

PubChem ID

46785920

InChI Key

UTAJHKSGYJSZBR-UHFFFAOYSA-N

SMILES

CC1=CC=CC(C(NC2=CC(NC(C3=CC=CC=C3OC)=O)=CC=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.04 100
Ethanol 18.02 50

Preparing Stock Solutions for ML 365

The following data is based on the product molecular weight 360.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for ML 365

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 365

For research use only

Customer Reviews for ML 365 (1)

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  • Ml 365 used to study the channel blocking activity on K2p1.1 channels
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/27/2018
    This product was used to study the channel blocking activity on K2p1.1 channels. It was identified that it shows certain degree of channel blocking although that is not concentration dependent. Would buy again as the results obtained were reproducible at every trial study.
    ML 365 5337

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