ML 67-33 New
Chemical Name: 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
Biological ActivityK2P potassium channel activator (EC50 values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Protein and chemical determinants of BL-1249 action and selectivity for K2P channels.
Pope et al.
ACS Chem.Neurosci., 2018;9:3153
A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
Bagriantsev et al.
ACS Chem.Biol., 2013;8:1841
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