ML 67-33

Key Product Details

Product Description

ML 67-33 is a K_2P potassium channel activator (EC₅₀ values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K_2P2.1 (TREK-1), K_2P10.1 (TREK-2) and K_2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels. In a mouse migraine model, ML 67-33 improves pain symptoms via activation of TREK 1/2 currents in trigeminal ganglion sensory neurons.

Product Specifications for ML 67-33

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 67-33

The following data is based on the product molecular weight 374.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.36 mL	26.72 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Pope Protein and chemical determinants of BL-1249 action and selectivity for K_2P channels. ACS Chem.Neurosci. 2018 PMID: 30089357
• Prado TREK channel activation suppresses migraine pain phenotype. iScience 2021 PMID: 34458705
• Bagriantsev A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K_2P channels. ACS Chem.Biol. 2013 PMID: 23738709

Product Documents for ML 67-33