ML SA1

Catalog # Availability Size / Price Qty
4746/10
4746/50
TRPML Channel Activators Small Molecule
1 Image
Description: Activator of TRPML channels

Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca 2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Technical Data

M.Wt:
362.42
Formula:
C22H22N2O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
332382-54-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for ML SA1

The citations listed below are publications that use Tocris products. Selected citations for ML SA1 include:

1 Citation: Showing 1 - 1

  1. Structural basis for PtdInsP2-mediated human TRPML1 regulation.
    Authors: Fine Et al.
    Nat.Commun.  2018;9:4192

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