Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Biological ActivityML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release.
Shen et al.
Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases.
Weiss et al.
Citation for ML SA1
The citations listed below are publications that use Tocris products. Selected citations for ML SA1 include:
1 Citation: Showing 1 - 1
Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Authors: Fine Et al.
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