Selective competitive inhibitor of myosin light chain kinase (IC50
= 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
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All Tocris products are intended for laboratory research use only.
Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge.
Lukas et al.
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.
Zolotarevsky et al.
The citations listed below are publications that use Tocris products. Selected citations for MLCK inhibitor peptide 18 include:
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