Catalog Number: 1885
Alternate Names: Myosin Light Chain Kinase Inhibitor Peptide 18
Biological Activity
Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
Technical Data
  • M.Wt:
    1324.64
  • Formula:
    C60H105N23O11
  • Sequence:
    RKKYKYRRK

    (Modifications: Lys-9 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    224579-74-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge.
    Lukas et al.
    J.Med.Chem., 1999;42:910
  2. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.
    Zolotarevsky et al.
    Gastroenterology, 2002;123:163
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MLCK inhibitor peptide 18 include:

1 Citations: Showing 1 - 1

  1. Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A 2012;61:2134

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