MLCK inhibitor peptide 18
Biological ActivitySelective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
(Modifications: Lys-9 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.
Zolotarevsky et al.
Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge.
Lukas et al.
Citation for MLCK inhibitor peptide 18
The citations listed below are publications that use Tocris products. Selected citations for MLCK inhibitor peptide 18 include:
1 Citation: Showing 1 - 1
Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
Authors: Wang Et al.
Proc Natl Acad Sci U S A 2012;61:2134
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