MLCK inhibitor peptide 18

Name: MLCK inhibitor peptide 18
Brand: Tocris Bioscience
SKU: 1885
Price: 129 USD
Availability: InStock

Tocris Bioscience | Catalog # 1885

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Citations (3)

Product Documents

Selective inhibitor of myosin light chain kinase

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective inhibitor of myosin light chain kinase

Alternative Names

Myosin Light Chain Kinase Inhibitor Peptide 18

View all Myosin Light Chain Kinase Inhibitors »

Product Description

MLCK inhibitor peptide 18 is a selective competitive inhibitor of myosin light chain kinase (IC₅₀ = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.

Product Specifications for MLCK inhibitor peptide 18

Molecular Weight

1324.64

Formula

C₆₀H₁₀₅N₂₃O₁₁

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

224579-74-2

PubChem ID

10102940

InChI Key

JPOKAKNGULMYHZ-UILVTTEASA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Zolotarevsky A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 2002 PMID: 12105845
Lukas Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 1999 PMID: 10072688

Product Documents for MLCK inhibitor peptide 18

Certificate of Analysis

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Product Specific Notices for MLCK inhibitor peptide 18

For research use only

Citations for MLCK inhibitor peptide 18

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