Chemical Name: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
Biological ActivityMLS 1547 is a G protein-biased D2 receptor partial agonist (Ki = 1.2 μM). Stimulates D2 receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D2 receptors.
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Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 DA receptor.
Free et al.
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