MLS 1547

Key Product Details

Product Description

MLS 1547 is a G protein-biased D₂ receptor partial agonist (K_i = 1.2 μM). Stimulates D₂ receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D₂ receptors.

Product Specifications for MLS 1547

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MLS 1547

The following data is based on the product molecular weight 354.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.09 mL	28.18 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Free Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D₂ DA receptor. Mol.Pharmacol. 2014 PMID: 24755247

Product Documents for MLS 1547