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MMPIP hydrochloride

Catalog #: 2963
4 Citations Datasheet / COA / SDS

Discontinued Product

2963 has been discontinued.
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MMPIP hydrochloride | CAS No. 1215566-78-1 | Group III mGluR Antagonists
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Description: Potent and selective negative allosteric modulator of mGlu7 receptors

Chemical Name: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.

Technical Data

M.Wt:
369.8
Formula:
C19H15N3O3.HCl
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1215566-78-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for MMPIP hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:

4 Citations: Showing 1 - 4

  1. New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection.
    Authors: Jantas Et al.
    Neuropharmacology  2018;141:223
  2. Constitutive activity of metabotropic glutamate receptor 7.
    Authors: Kammermeier
    Front Pediatr  2015;16:17
  3. Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
    Authors: Johansson Et al.
    Cell Rep.  2015;13:1741
  4. Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat.
    Authors: Palazzo Et al.
    Mol Pain  2013;9:44

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