Chemical Name: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
Biological ActivityMMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.
Suzuki et al.
Citations for MMPIP hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:
4 Citations: Showing 1 - 4
New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection.
Authors: Jantas Et al.
Constitutive activity of metabotropic glutamate receptor 7.
Front Pediatr 2015;16:17
Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
Authors: Johansson Et al.
Cell Rep. 2015;13:1741
Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat.
Authors: Palazzo Et al.
Mol Pain 2013;9:44
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