Potent allosteric mGlu7
-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50
values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50
= 15 nM), indicating inverse agonist activity.
Soluble to 10 mM in DMSO
Desiccate at RT
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All Tocris products are intended for laboratory research use only.
In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.
Suzuki et al.
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