MMPIP hydrochloride

Tocris Bioscience | Catalog # 2963

Potent and selective negative allosteric modulator of mGlu7 receptors
Tocris Bioscience
Discontinued Product
2963 has been discontinued. View all Group III mGluR Antagonists products.

Key Product Details

Description

Potent and selective negative allosteric modulator of mGlu7 receptors
View all Group III mGluR Antagonists »

Product Description

MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.

Product Specifications for MMPIP hydrochloride

Molecular Weight

369.80

Formula

C19H15N3O3.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride

CAS Number

1215566-78-1

PubChem ID

52974245

InChI Key

HXHQNERSIJXMTQ-UHFFFAOYSA-N

SMILES

O=C1N(C)C(C3=CC=C(OC)C=C3)=CC2=C1C(C4=CC=NC=C4)=NO2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.7 10

Preparing Stock Solutions for MMPIP hydrochloride

The following data is based on the product molecular weight 369.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.04 mL 135.21 mL 270.42 mL
0.5 mM 5.41 mL 27.04 mL 54.08 mL
1 mM 2.70 mL 13.52 mL 27.04 mL
5 mM 0.54 mL 2.70 mL 5.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for MMPIP hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MMPIP hydrochloride

For research use only

Citations for MMPIP hydrochloride

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