MMPIP hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2963
Chemical Name:6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
Product Details
Citations (3)
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Reviews
Biological Activity
Potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.
Technical Data
  • M.Wt:
    369.8
  • Formula:
    C19H15N3O3.HCl
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    479077-02-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Constitutive activity of metabotropic glutamate receptor 7.
    Authors: Kammermeier
    Front Pediatr  2015;16:17
  2. Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
    Authors: Johansson Et al.
    Cell Rep.  2015;13:1741
  3. Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat.
    Authors: Palazzo Et al.
    Mol Pain  2013;9:44

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