Selective negative allosteric modulator of group II mGlu receptors (IC50
values are 8.3 and 12.6 nM for human and rat mGlu2
inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu1
receptors in a calcium mobilization assay.
Soluble to 50 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.
Hemstapat et al.