MNI 137

Catalog # Availability Size / Price Qty
4388/10
4388/50
Cat.No. 4388 - MNI 137 | C15H9BrN4O | CAS No. 946619-21-2
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Description: Selective negative allosteric modulator of group II mGlu receptors

Chemical Name: 4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile

Purity: ≥98%

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Biological Activity

Selective negative allosteric modulator of group II mGlu receptors (IC50 values are 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu1, mGlu4, mGlu5 or mGlu8 receptors in a calcium mobilization assay.

Technical Data

M.Wt:
341.16
Formula:
C15H9BrN4O
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
946619-21-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.
    Hemstapat et al.
    J.Pharmacol.Exp.Ther., 2007;322:254

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