Catalog Number: 2224
Alternate Names: 4-Methoxy-7-nitroindolinyl-caged N-methyl-D-aspartic acid
Chemical Name: (R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid
Biological Activity
NMDA (Cat.No. 0114) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Stoichiometrically releases chirally pure NMDA. Suitable for uncaging with 300-380 nm excitation. Improved localization can be achieved by uncaging at 405 nm (with mM concentration of caged compound in the bath solution). Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation.
Technical Data
  • M.Wt:
    323.3
  • Formula:
    C14H17N3O6
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    1227675-52-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the UK Medical Research Council
Background References
  1. New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.
    Palma-Cerda et al.
    Neuropharmacology., 2012;63:624
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MNI-caged-NMDA include:

1 Citations: Showing 1 - 1

  1. Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors.
    Authors: Zhang Et al.
    Nat.Commun. 2016;7:12650

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