Catalog Number: 0114
Chemical Name: N-Methyl-D-aspartic acid
Biological Activity
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™. Caged version also available (Cat. No 2224).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Excitatory amino acid transmitters.
    Watkins and Evans
    Annu.Rev.Pharmacol.Toxicol., 1981;21:165

The citations listed below are publications that use Tocris products. Selected citations for NMDA include:

Showing Results 1 - 10 of 70

  1. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.
    Authors: Reinhard Et al.
    Nat Commun
  2. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
    Authors: Eckel Et al.
  3. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
    Authors: Bertrand Et al.
    Cell Death Dis
  4. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis
  5. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    Nat Commun
  6. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
  7. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
  8. Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.
    Authors: Iskandrani Et al.
    J Psychopharmacol
  9. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    PLoS One
  10. Neuritin can normalize neural deficits of Alzheimer's disease.
    Authors: An Et al.
    Cell Death Dis
  11. Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice.
    Authors: Aligny Et al.
    Cell Death Dis
  12. Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction.
    Authors: Chen Et al.
    Nat Commun
  13. IKK regulates the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    Biochem Biophys Res Commun
  14. STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ.
    Authors: Hsu Et al.
  15. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci
  16. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol
  17. PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity.
    Authors: Antoniou Et al.
    EMBO Rep
  18. Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.
    Authors: Yang Et al.
    PLoS One
  19. Evidence for glutamate as a neuroglial transmitter within sensory ganglia.
    Authors: Kung Et al.
    PLoS One
  20. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain
  21. Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.
    Authors: Tupone Et al.
    J Neurosci
  22. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    J Neurosci
  23. On the selectivity of neuronal NOS inhibitors.
    Authors: Pigott Et al.
    Br J Pharmacol
  24. Physiological release of endogenous tau is stimulated by neuronal activity.
    Authors: Pooler Et al.
    EMBO Rep
  25. S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.
    Authors: Selvakumar Et al.
    Proc Natl Acad Sci U S A
  26. Gephyrin-independent GABA(A)R mobility and clustering during plasticity.
    Authors: Niwa Et al.
    PLoS One
  27. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
    Authors: Huang Et al.
    PLoS One
  28. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int
  29. Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.
    Authors: Cunningham Et al.
  30. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Authors: Owaisat Et al.
    Neurosci Lett
  31. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
    Authors: Udagawa Et al.
    Mol Cell
  32. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
    Authors: Tallarida Et al.
    Amino Acids
  33. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
    Authors: Rodríguez-Muñoz Et al.
  34. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
    Authors: Wang Et al.
    J Neurosci
  35. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci
  36. Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons.
    Authors: He Et al.
  37. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity.
    Authors: Bahia Et al.
    J Neurochem
  38. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.
    Authors: Li Et al.
    J Neuroinflammation
  39. Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission.
    Authors: Fontainhas Et al.
    PLoS One
  40. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
    Authors: Wang and Green
    J Neurosci
  41. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    J Neurosci
  42. SynGAP moves out of the core of the postsynaptic density upon depolarization.
    Authors: Yang Et al.
  43. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
  44. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
    Authors: Meissirel Et al.
    Proc Natl Acad Sci U S A
  45. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol
  46. Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
    Authors: Pansiot Et al.
    PLoS One
  47. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem
  48. NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.
    Authors: Baron Et al.
    Cell Death Differ
  49. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.
    Authors: Marignier Et al.
  50. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One
  51. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    Eur J Neurosci
  52. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
    Authors: Iwasato Et al.
    J Neurosci
  53. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
    Authors: Furness Et al.
  54. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    Proc Natl Acad Sci U S A
  55. AMPAR exocytosis through NO modulation of PICK1.
    Authors: Sossa Et al.
  56. Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices.
    Authors: Holman Et al.
  57. Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.
    Authors: Iida Et al.
    Mol Cell Biol
  58. Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus.
    Authors: Davidkova and Carroll
    J Neurosci
  59. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Nat Neurosci
  60. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
    Authors: Smith Et al.
    J Neurosci
  61. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol
  62. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    J Biol Chem
  63. Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
    Authors: Lesne Et al.
    J Biol Chem
  64. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    J Neurosci
  65. Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
    Authors: Nakayama Et al.
    J Neurosci
  66. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
    Authors: Lea Et al.
    Br J Pharmacol
  67. Cell type-specific interleukin-1beta signaling in the CNS.
    Authors: Srinivasan Et al.
    J Neurosci
  68. Subpallial origin of a population of projecting pioneer neurons during corticogenesis.
    Authors: Morante-Oria Et al.
    Proc Natl Acad Sci U S A
  69. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Proc Natl Acad Sci U S A
  70. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
    Authors: O'Leary Et al.
    Br J Pharmacol
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