NMDA

Tocris Bioscience | Catalog # 0114

Selective NMDA agonist
Tocris Bioscience

Key Product Details

Description

Selective NMDA agonist
View all NMDA Receptor Agonists »

Product Description

NMDA is a prototypic NMDA receptor agonist.

Caged version also available (Cat. No 2224).

Product Specifications for NMDA

Molecular Weight

147.13

Formula

C5H9NO4

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-Methyl-D-aspartic acid

CAS Number

6384-92-5

PubChem ID

4376

InChI Key

HOKKHZGPKSLGJE-UHFFFAOYSA-N

SMILES

O=C(C(NC)CC(=O)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.71 100

Preparing Stock Solutions for NMDA

The following data is based on the product molecular weight 147.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.80 mL 33.98 mL 67.97 mL
5 mM 1.36 mL 6.80 mL 13.59 mL
10 mM 0.68 mL 3.40 mL 6.80 mL
50 mM 0.14 mL 0.68 mL 1.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 1445 publications citing the usage of this product.

  • Watkins Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E
  • Watkins and Evans Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 1981 PMID: 6112965

Product Documents for NMDA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NMDA

For research use only

Customer Reviews for NMDA (6)

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  • NMDA to induce DSBs
    Name: Xiaoyu Zhang
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: neuron cells
    Verified Customer | Posted 06/23/2023
    Neurons were treated with 1 mM NMDA, followed by IF staining for NMDA receptors (green) and DSBs (red).
    NMDA 0114
  • Glutamate agonist
    Name: Karthik Krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: spinal cord neurons
    Verified Customer | Posted 08/03/2021
    For calcium imaging in motor neurons and other spinal neurons. 50 micromolar was used to stimulate neuronal cultures for 90 seconds. Time course of cytosolic calcium influx was measured using ratiometric calcium indicator Fura2-AM.
    NMDA 0114
  • Great product
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: neurons
    Verified Customer | Posted 06/15/2020
    25uM
    NMDA 0114
  • reliable product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    treat 50 μM NMDA for 10 min
    NMDA 0114
  • Activation of NMDA receptors in outside-out patches
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 10/19/2019
    Should be used instead of glutamate for selective activation of NMDA receptors
    Mixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response without contamination from other glutamate receptors in outside-out patched excised from hippocampal neurons. NMDA displayed a clear agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.
    NMDA 0114
  • Induction of chemLTD
    Name: Anonymous
    Assay Type: Ex Vivo
    Verified Customer | Posted 11/02/2017
    Used at 20uM for 3 minutes to induce chemLTD.
    Application of NMDA was used to induce synaptic depression in acute brain slice.
    NMDA 0114

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