NMDA

  ( 78 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0114
Chemical Name:N-Methyl-D-aspartic acid
Product Details
Citations (78)
Supplemental Products
Reviews
Biological Activity
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™. Caged version also available (Cat. No 2224).
Technical Data
  • M.Wt:
    147.13
  • Formula:
    C5H9NO4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    6384-92-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NMDA include:

78 Citations: Showing 1 - 10
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  1. The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental areamediate morphine-induced memory consolidation impairment.
    Authors: Sharifi
    Neuroscience  2017;353:7
  2. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.
    Authors: Reinhard Et al.
    Nat Commun  2016;7:11613
  3. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
    Authors: Eckel Et al.
    Neuropharmacology  2015;88:82
  4. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
    Authors: Bertrand Et al.
    Cell Death Dis  2015;6:e1924
  5. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis  2015;6:e1645
  6. The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
    Authors: Grosso Et al.
    Nat Commun  2015;6:8886
  7. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    Nat Commun  2015;6:7066
  8. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Oncotarget  2015;6:35458
  9. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Glia  2015;63:383
  10. Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.
    Authors: Iskandrani Et al.
    J Psychopharmacol  2015;29:792
  11. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    PLoS One  2014;9:e91312
  12. Neuritin can normalize neural deficits of Alzheimer's disease.
    Authors: An Et al.
    Cell Death Dis  2014;5:e1523
  13. Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice.
    Authors: Aligny Et al.
    Cell Death Dis  2014;5:e1311
  14. Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction.
    Authors: Chen Et al.
    Nat Commun  2014;5:5331
  15. IKK regulates the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    Biochem Biophys Res Commun  2014;450:550
  16. STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ.
    Authors: Hsu Et al.
    Neuropsychopharmacology  2014;39:746
  17. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci  2014;369:20130158
  18. Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation.
    Authors: Fan Et al.
    Nat Neurosci  2014;17:471
  19. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol  2014;17:1943
  20. PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity.
    Authors: Antoniou Et al.
    EMBO Rep  2014;15:548
  21. Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.
    Authors: Yang Et al.
    PLoS One  2013;8:e71795
  22. Evidence for glutamate as a neuroglial transmitter within sensory ganglia.
    Authors: Kung Et al.
    PLoS One  2013;8:e68312
  23. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  24. Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.
    Authors: Tupone Et al.
    J Neurosci  2013;33:14512
  25. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    J Neurosci  2013;33:11206
  26. On the selectivity of neuronal NOS inhibitors.
    Authors: Pigott Et al.
    Br J Pharmacol  2013;168:1255
  27. Physiological release of endogenous tau is stimulated by neuronal activity.
    Authors: Pooler Et al.
    EMBO Rep  2013;14:389
  28. S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.
    Authors: Selvakumar Et al.
    Proc Natl Acad Sci U S A  2013;110:1077
  29. Gephyrin-independent GABA(A)R mobility and clustering during plasticity.
    Authors: Niwa Et al.
    PLoS One  2012;7:e36148
  30. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
    Authors: Huang Et al.
    PLoS One  2012;7:e30662
  31. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int  2012;61:601
  32. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine.
    Authors: Beard Et al.
    Vascul Pharmacol  2012;56:159
  33. Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.
    Authors: Cunningham Et al.
    Epilepsia  2012;53:1205
  34. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Authors: Owaisat Et al.
    Neurosci Lett  2012;525:12
  35. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
    Authors: Udagawa Et al.
    Mol Cell  2012;47:253
  36. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
    Authors: Tallarida Et al.
    Amino Acids  2012;42:2521
  37. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
    Authors: Rodríguez-Muñoz Et al.
    Neuropsychopharmacology  2012;37:338
  38. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
    Authors: Wang Et al.
    J Neurosci  2012;32:9773
  39. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci  2012;32:5186
  40. Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons.
    Authors: He Et al.
    FASEB J  2012;26:334
  41. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity.
    Authors: Bahia Et al.
    J Neurochem  2012;123:182
  42. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.
    Authors: Li Et al.
    J Neuroinflammation  2011;8:15
  43. Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission.
    Authors: Fontainhas Et al.
    PLoS One  2011;6:e15973
  44. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
    Authors: Wang and Green
    J Neurosci  2011;31:7938
  45. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    J Neurosci  2011;31:3077
  46. SynGAP moves out of the core of the postsynaptic density upon depolarization.
    Authors: Yang Et al.
    Neuroscience  2011;192:132
  47. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
    Neuroscience  2011;189:305
  48. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
    Authors: Meissirel Et al.
    Proc Natl Acad Sci U S A  2011;108:13782
  49. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol  2011;105:1051
  50. Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
    Authors: Pansiot Et al.
    PLoS One  2010;5:e10916
  51. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem  2010;285:35606
  52. NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.
    Authors: Baron Et al.
    Cell Death Differ  2010;17:860
  53. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.
    Authors: Marignier Et al.
    Brain  2010;133:2578
  54. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One  2009;4:e6011
  55. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    Eur J Neurosci  2009;30:1443
  56. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
    Authors: Iwasato Et al.
    J Neurosci  2008;28:5931
  57. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
    Authors: Furness Et al.
    Neuroscience  2008;157:80
  58. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    Proc Natl Acad Sci U S A  2008;105:9093
  59. AMPAR exocytosis through NO modulation of PICK1.
    Authors: Sossa Et al.
    Neuropharmacology  2007;53:92
  60. Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices.
    Authors: Holman Et al.
    Neuropharmacology  2007;52:92
  61. Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.
    Authors: Iida Et al.
    Mol Cell Biol  2007;27:4388
  62. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
    Authors: Marsden Et al.
    J Neurosci  2007;27:14326
  63. Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus.
    Authors: Davidkova and Carroll
    J Neurosci  2007;27:13273
  64. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Nat Neurosci  2007;10:321
  65. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism.
    Authors: Jiang Et al.
    J Neurosci  2006;26:4318
  66. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
    Authors: Smith Et al.
    J Neurosci  2006;26:2391
  67. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591
  68. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    J Biol Chem  2005;280:38121
  69. Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
    Authors: Lesne Et al.
    J Biol Chem  2005;280:24941
  70. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    J Neurosci  2005;25:4288
  71. Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
    Authors: Nakayama Et al.
    J Neurosci  2005;25:4040
  72. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
    Authors: Lea Et al.
    Br J Pharmacol  2005;145:527
  73. beta-estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-methyl-D-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms.
    Authors: Kurata Et al.
    J Pharmacol Exp Ther  2004;311:237
  74. Cell type-specific interleukin-1beta signaling in the CNS.
    Authors: Srinivasan Et al.
    J Neurosci  2004;24:6482
  75. Subpallial origin of a population of projecting pioneer neurons during corticogenesis.
    Authors: Morante-Oria Et al.
    Proc Natl Acad Sci U S A  2003;100:12468
  76. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Proc Natl Acad Sci U S A  2000;97:11593
  77. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
    Authors: O'Leary Et al.
    Br J Pharmacol  2000;131:1429
  78. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
    Authors: Fedele Et al.
    Br J Pharmacol  1996;119:590
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 Induction of chemLTD 0114 Array 0114
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  Mouse Anonymous 11/02/2017
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 Induction of chemLTD 0114
: Induction of chemLTD [0114].

Summary

Species Mouse

Other Experimental Details

Other Experimental Details Used at 20uM for 3 minutes to induce chemLTD.

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