Catalog Number: 0114
Chemical Name: N-Methyl-D-aspartic acid
Biological Activity
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™. Caged version also available (Cat. No 2224).
Technical Data
  • M.Wt:
    147.13
  • Formula:
    C5H9NO4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    6384-92-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Excitatory amino acid transmitters.
    Watkins and Evans
    Annu.Rev.Pharmacol.Toxicol., 1981;21:165
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NMDA include:

71 Citations: Showing 1 - 10
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  1. The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental areamediate morphine-induced memory consolidation impairment.
    Authors: Sharifi
    Neuroscience 2017;353:7
  2. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.
    Authors: Reinhard Et al.
    Nat Commun 2016;7:11613
  3. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
    Authors: Eckel Et al.
    Neuropharmacology 2015;88:82
  4. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
    Authors: Bertrand Et al.
    Cell Death Dis 2015;6:e1924
  5. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis 2015;6:e1645
  6. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    Nat Commun 2015;6:7066
  7. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Oncotarget 2015;6:35458
  8. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Glia 2015;63:383
  9. Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.
    Authors: Iskandrani Et al.
    J Psychopharmacol 2015;29:792
  10. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    PLoS One 2014;9:e91312
  11. Neuritin can normalize neural deficits of Alzheimer's disease.
    Authors: An Et al.
    Cell Death Dis 2014;5:e1523
  12. Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice.
    Authors: Aligny Et al.
    Cell Death Dis 2014;5:e1311
  13. Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction.
    Authors: Chen Et al.
    Nat Commun 2014;5:5331
  14. IKK regulates the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    Biochem Biophys Res Commun 2014;450:550
  15. STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ.
    Authors: Hsu Et al.
    Neuropsychopharmacology 2014;39:746
  16. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci 2014;369:20130158
  17. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol 2014;17:1943
  18. PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity.
    Authors: Antoniou Et al.
    EMBO Rep 2014;15:548
  19. Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.
    Authors: Yang Et al.
    PLoS One 2013;8:e71795
  20. Evidence for glutamate as a neuroglial transmitter within sensory ganglia.
    Authors: Kung Et al.
    PLoS One 2013;8:e68312
  21. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain 2013;6:42
  22. Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.
    Authors: Tupone Et al.
    J Neurosci 2013;33:14512
  23. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    J Neurosci 2013;33:11206
  24. On the selectivity of neuronal NOS inhibitors.
    Authors: Pigott Et al.
    Br J Pharmacol 2013;168:1255
  25. Physiological release of endogenous tau is stimulated by neuronal activity.
    Authors: Pooler Et al.
    EMBO Rep 2013;14:389
  26. S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.
    Authors: Selvakumar Et al.
    Proc Natl Acad Sci U S A 2013;110:1077
  27. Gephyrin-independent GABA(A)R mobility and clustering during plasticity.
    Authors: Niwa Et al.
    PLoS One 2012;7:e36148
  28. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
    Authors: Huang Et al.
    PLoS One 2012;7:e30662
  29. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int 2012;61:601
  30. Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.
    Authors: Cunningham Et al.
    Epilepsia 2012;53:1205
  31. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Authors: Owaisat Et al.
    Neurosci Lett 2012;525:12
  32. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
    Authors: Udagawa Et al.
    Mol Cell 2012;47:253
  33. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
    Authors: Tallarida Et al.
    Amino Acids 2012;42:2521
  34. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
    Authors: Rodríguez-Muñoz Et al.
    Neuropsychopharmacology 2012;37:338
  35. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
    Authors: Wang Et al.
    J Neurosci 2012;32:9773
  36. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci 2012;32:5186
  37. Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons.
    Authors: He Et al.
    FASEB J 2012;26:334
  38. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity.
    Authors: Bahia Et al.
    J Neurochem 2012;123:182
  39. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.
    Authors: Li Et al.
    J Neuroinflammation 2011;8:15
  40. Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission.
    Authors: Fontainhas Et al.
    PLoS One 2011;6:e15973
  41. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
    Authors: Wang and Green
    J Neurosci 2011;31:7938
  42. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    J Neurosci 2011;31:3077
  43. SynGAP moves out of the core of the postsynaptic density upon depolarization.
    Authors: Yang Et al.
    Neuroscience 2011;192:132
  44. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
    Neuroscience 2011;189:305
  45. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
    Authors: Meissirel Et al.
    Proc Natl Acad Sci U S A 2011;108:13782
  46. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol 2011;105:1051
  47. Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
    Authors: Pansiot Et al.
    PLoS One 2010;5:e10916
  48. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem 2010;285:35606
  49. NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.
    Authors: Baron Et al.
    Cell Death Differ 2010;17:860
  50. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.
    Authors: Marignier Et al.
    Brain 2010;133:2578
  51. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One 2009;4:e6011
  52. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    Eur J Neurosci 2009;30:1443
  53. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
    Authors: Iwasato Et al.
    J Neurosci 2008;28:5931
  54. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
    Authors: Furness Et al.
    Neuroscience 2008;157:80
  55. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    Proc Natl Acad Sci U S A 2008;105:9093
  56. AMPAR exocytosis through NO modulation of PICK1.
    Authors: Sossa Et al.
    Neuropharmacology 2007;53:92
  57. Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices.
    Authors: Holman Et al.
    Neuropharmacology 2007;52:92
  58. Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.
    Authors: Iida Et al.
    Mol Cell Biol 2007;27:4388
  59. Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus.
    Authors: Davidkova and Carroll
    J Neurosci 2007;27:13273
  60. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Nat Neurosci 2007;10:321
  61. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
    Authors: Smith Et al.
    J Neurosci 2006;26:2391
  62. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol 2006;16:1591
  63. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    J Biol Chem 2005;280:38121
  64. Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
    Authors: Lesne Et al.
    J Biol Chem 2005;280:24941
  65. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    J Neurosci 2005;25:4288
  66. Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
    Authors: Nakayama Et al.
    J Neurosci 2005;25:4040
  67. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
    Authors: Lea Et al.
    Br J Pharmacol 2005;145:527
  68. Cell type-specific interleukin-1beta signaling in the CNS.
    Authors: Srinivasan Et al.
    J Neurosci 2004;24:6482
  69. Subpallial origin of a population of projecting pioneer neurons during corticogenesis.
    Authors: Morante-Oria Et al.
    Proc Natl Acad Sci U S A 2003;100:12468
  70. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Proc Natl Acad Sci U S A 2000;97:11593
  71. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
    Authors: O'Leary Et al.
    Br J Pharmacol 2000;131:1429
Expand to show all 71 Citations
Average Rating: 5 (Based on 1 review)

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 Induction of chemLTD 0114
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  Anonymous 11/02/2017
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 Induction of chemLTD 0114
: Induction of chemLTD [0114]

Other Experimental Details

Other Experimental DetailsUsed at 20uM for 3 minutes to induce chemLTD.

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