Detection of ChemR23 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse ChemR23 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # FAB7610G, filled histogram) or isotype control antibody (Catalog # IC013G, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
ChemR23 is a chemoattractant receptor expressed on dendritic cells and inflammatory M1 macrophages. ChemR23 binds Chemerin and Resolvin E1 (a lipid mediator), and promotes inflammation resolution. ChemR23 also functions as a coreceptor for SIV and some primary HIV-1 strains (1,2). Mouse and human ChemR23 share 80% amino acid sequence identity.
Samson, M. et al. (1998) Eur. J. Immunol. 28:1689.
Herova, M. et al. (2015) J. Immunol. 194:2330.
Chemokine-like Receptor 1/Orphan G Protein-coupled Receptor ChemR23
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