Mouse Nogo-B Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Nogo-B

Nogo-B, also known as ASY, is a 55 kDa splice form of Nogo-A/Reticulon-4 and is primarily expressed in vascular endothelial cells. Nogo-A contains a large N‑terminal cytoplasmic domain and a reticulon region that consists of two transmembrane segments with an intervening noncytoplasmic domain. Nogo-B lacks most of the N-terminal domain but retains the reticulon domain. It inhibits neointimal hyperplasia in the vasculature and is downregulated in atherosclerotic tissue and thoracic arterial aneurisms. Interaction of Nogo-B with NgBR promotes endothelial cell proliferation and migration. Within aa 1‑183, mouse Nogo-B shares 76% and 94% aa sequence identity with human and rat Nogo-B, respectively.

Product Datasheets

Related Research Areas

• Multiple Sclerosis and Myelin Related Molecules
• Nogo Proteins and Receptors