Mouse PDGFRL Alexa Fluor™ Plus 647‑conjugated Antibody

R&D Systems | Catalog # FAB9739AFP647

R&D Systems

Key Product Details

Species Reactivity

Mouse

Applications

Neutralization

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Monoclonal Rat IgG2B Clone # 1010639
View all PDGFRL Primary Antibodies »

Product Specifications

Specificity

Detects mouse PDGFRL in direct ELISAs.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Applications for Mouse PDGFRL Alexa Fluor™ Plus 647‑conjugated Antibody

Application
Recommended Usage

Neutralization

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PDGFRL

Platelet-derived growth factor receptor-like protein (PDGFRL) is a 67 kDa glycoprotein protein consisting of two Ig-like C2-type domains. By sequence similarity, mouse PDGFRL is 90% similar to the human version and 95% similar to that of the rat. It is a secreted protein related to the class III subfamily of receptor tyrosine kinases (RTK), the platelet-derived growth factor receptors (1-5). The high frequency of loss of heterozygosity (LOH) near the gene of PDGFRL indicated in several studies that PDGFRL can be a tumor suppressor gene (TSG) in breast cancer (6-9), colorectal cancer, prostate cancer (10), non-small cell lung cancers (11) and hepatocellular carcinoma (12). A variant of PDGFRL is found to play a role in the development of Behçet disease, a complex immunoregulatory disease (13). The autoimmune role of PDGFRL is also supported by its up-regulation in a mouse model for Rheumatoid Arthritis (14). Another study also showed that PDGFRL may play a role in chondrocyte proliferation and differentiation (15).

References

  1. Guo, F-J. et al. (2010). World J Gastroenterol. 16:1465.
  2. Andrae, J. et al. (2008) Genes Dev. 22:1276.
  3. Heldin, C-H. and B. Westermark (1999) Physiol. Rev. 79:1283.
  4. Claesson-Welsh, L. et al. (1989) Proc. Natl. Acad. Sci. USA 86:4917.
  5. Matsui, T. et al. (1989) Science 243:800.
  6. Seitz, S. et al. (2006). Genes Chromosomes Cancer 45:612.
  7. Yaremko, M.L. et al. (1996). Genes, Chromosome Cancer 16:189.
  8. Seitz, S. et al. (2000). Eur J Cancer. 36:1507.
  9. Rennstam, K. et al. (2003). Cancer Res. 63:8861.
  10. Komiya, A. et al. (1997). Jpn J Cancer Res. 88:389.
  11. Lerebours, F. et al. (1999). Int J Cancer. 81:854.
  12. Kahng, Y.S. et al. (2003) J Gastroenterol Hepatol. 18:430.
  13. Hou, S. et al. (2013). Hum Mutat. 34:74.
  14. Fujikado N. et al. (2006). Arthritis Res.& Ther. 8:R100.
  15. Kawata, K. et al. (2017) J Cell Biochemistry. 118:4033.

Long Name

Platelet-derived Growth Factor Receptor-like

Alternate Names

PDGFR-Like Protein, PDGRL, PRLTS

Entrez Gene IDs

5157 (Human); 68797 (Mouse); 290771 (Rat)

Gene Symbol

PDGFRL

UniProt

Q6PE55

Additional PDGFRL Products

Product Documents for Mouse PDGFRL Alexa Fluor™ Plus 647‑conjugated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Mouse PDGFRL Alexa Fluor™ Plus 647‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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