Mouse Serpin B8/Proteinase Inhibitor 8 Alexa Fluor™ Plus 405‑conjugated Antibody

R&D Systems | Catalog # AF3588AFP405

R&D Systems

Key Product Details

Species Reactivity

Mouse

Applications

Western Blot, Immunoprecipitation

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Polyclonal Goat IgG
View all Serpin B8/Proteinase Inhibitor 8 Primary Antibodies »

Product Specifications

Specificity

Detects mouse Serpin B8/Proteinase Inhibitor 8 in direct ELISAs and Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) Serpin B8, rhSerpin B9, and rhSerpin B6 is observed and less than 1% cross-reactivity with rhSerpin A1, D1, E2, I2, recombinant mouse Serpin A1, C1, E1, F1, and F2 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications

Application
Recommended Usage

Immunoprecipitation

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Serpin B8/Proteinase Inhibitor 8

Serpin B8, also known as Proteinase Inhibitor 8 (PI8) and cytoplasmic antiproteinase 2 (CAP2), is a member of the Serpin superfamily of the serine protease inhibitors (1). It inhibits furin, a ubiquitously expressed convertase that processes many pro-proteins (2). Distribution of Serpin B8 alters during kidney regeneration, indicating that it plays a role in inflammation or tissue repair (3).

References

  1. Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
  2. Dahlen, J.R. et al. (1998) J. Biol. Chem. 273:1851.
  3. Gillard, A. (2006) Am. J. Nephrol. 26:34.
    4. .

Alternate Names

CAP2, NK10, PI8

Entrez Gene IDs

5271 (Human); 20725 (Mouse); 288937 (Rat)

Gene Symbol

SERPINB8

UniProt

O08800

Additional Serpin B8/Proteinase Inhibitor 8 Products

Product Documents

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Serine Proteases and Regulators

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