MPD 2

Tocris Bioscience | Catalog # 8802

SARS-CoV-2 Mpro Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

SARS-CoV-2 Mpro Degrader (PROTAC®)
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Product Description

MPD 2 is a SARS-CoV-2 Mpro Degrader (PROTAC®) (DC50 = 296 nM in 293T cells). Mpro degradation is time-dependent and CRBN-mediated. Antiviral in A549-ACE2 cells infected with several SARS-CoV-2 strains (EC50 = 492 nM at delta variant) and against a nirmatrelvir-resistant mutant of SARS-CoV-2, NSP5 E166A (EC50 = 460 nM).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Scientific Data Images for MPD 2

Application of MPD 2

Application of MPD 2.

Western blot data showing dose responsive degradation with MPD 2 on transiently expressed SARS-CoV-2 Main Protease in HEK293 cells. 1st Ab: HRP Anti-V5 tag antibody [E10/V4RR] (ab173837) (1:2000), 2nd Ab: Anti-Mouse HRP (1:5000). Loading control: 1st Ab: Anti-alpha - Tubulin antibody [DM1A] - (1:10000) 2nd Ab: Anti-mouse HRP (1:5000). Data provided by Brönstrup Lab at the Helmholtz Centre for Infection Research.

Product Specifications for MPD 2

Molecular Weight

973.13

Formula

C51H68N6O13

Storage

Store at -20°C

Chemical Name

3-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)oxy)benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

PubChem ID

171663340

InChI Key

ZKSDAFLRLHGTNH-DTKLLKMQSA-N

SMILES

O=C1[C@@H](CCN1)C[C@H](NC([C@@H](NC([C@@H](NC(OCC2=CC(OCCCCCCOC3=C4C(C(N(C4=O)C5CCC(NC5=O)=O)=O)=CC=C3)=CC=C2)=O)[C@@H](C)OC(C)(C)C)=O)CC6CCCCC6)=O)C([H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 97.31 100

Preparing Stock Solutions for MPD 2

The following data is based on the product molecular weight 973.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.14 mL 10.28 mL
5 mM 0.21 mL 1.03 mL 2.06 mL
10 mM 0.10 mL 0.51 mL 1.03 mL
50 mM 0.02 mL 0.10 mL 0.21 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MPD 2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MPD 2

For research use only

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