Catalog Number: 0853
Chemical Name: (RS)-α-Methyl-4-phosphonophenylglycine
Biological Activity
Potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices.
Technical Data
  • M.Wt:
    245.17
  • Formula:
    C9H12NO5P
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Storage:
    Store at RT
  • CAS No:
    169209-65-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors.
    Bedingfield et al.
    Eur.J.Pharmacol., 1996;309:71
  2. Pharmacological antagonism of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices.
    Bushell et al.
    Br.J.Pharmacol., 1996;117:1457
  3. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord.
    Jane et al.
    Neuropharmacology, 1995;34:851
  4. Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR anatagonist MPPG.
    Salt and Turner
    Neuropharmacology, 1996;35:239
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MPPG include:

1 Citations: Showing 1 - 1

  1. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    Mol Cancer Res 2015;10:e0125974

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