Mps BAY 2a

Catalog # Availability Size / Price Qty
5562/10
5562/50
Cat.No. 5562 - Mps BAY 2a | C29H28N6O | CAS No. 1382477-96-4
1 Image
Description: Potent and selective Mps1 kinase inhibitor

Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.

Technical Data

M.Wt:
476.57
Formula:
C29H28N6O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1382477-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Characterization of novel MPS1 inhibitors with preclinical anticancer activity.
    Jemaà et al.
    Cell Death Differ., 2013;20:1532

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for Mps BAY 2a

The citations listed below are publications that use Tocris products. Selected citations for Mps BAY 2a include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Mps BAY 2a

There are currently no reviews for this product. Be the first to review Mps BAY 2a and earn rewards!

Have you used Mps BAY 2a?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.