Biological Activity Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C
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For batch specific data refer to the Certificate of Analysis.
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