Mps BAY 2a
Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Biological ActivityPotent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of novel MPS1 inhibitors with preclinical anticancer activity.
Jemaà et al.
Cell Death Differ., 2013;20:1532
Citation for Mps BAY 2a
The citations listed below are publications that use Tocris products. Selected citations for Mps BAY 2a include:
1 Citation: Showing 1 - 1
TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.
Authors: Choi Et al.
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