Mps BAY 2a
Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Biological ActivityPotent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Characterization of novel MPS1 inhibitors with preclinical anticancer activity.
Jemaà et al.
Cell Death Differ., 2013;20:1532
Citation for Mps BAY 2a
The citations listed below are publications that use Tocris products. Selected citations for Mps BAY 2a include:
1 Citation: Showing 1 - 1
TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.
Authors: Choi Et al.
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