Catalog Number: 5562
Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Biological Activity
Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
Technical Data
  • M.Wt:
    476.57
  • Formula:
    C29H28N6O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1382477-96-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of novel MPS1 inhibitors with preclinical anticancer activity.
    Jemaà et al.
    Cell Death Differ., 2013;20:1532
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mps BAY 2a include:

1 Citations: Showing 1 - 1

  1. TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.
    Authors: Choi Et al.
    Br.J.Pharmacol. 2017;174:1810

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