MRS 1754

  ( 12 citations )    
Product Datasheet
Catalog Number:2752
Chemical Name:N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
Technical Data
  • M.Wt:
    486.52
  • Formula:
    C26H26N6O4
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming and to 10 mM in DMSO with sonication
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    264622-58-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Virginia Patent Foundation
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 1754 include:

12 Citations: Showing 1 - 10
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  1. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.
    Authors: Asano
    Scientific Reports  2017;7:40214
  2. Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
    Authors: Ledderose Et al.
    Purinergic Signalling  2016;
  3. Anti-inflammatory effects of adenosine N1-oxide.
    Authors: Kohno Et al.
    Am J Physiol Lung Cell Mol Physiol  2015;12:2
  4. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
    Authors: Welihinda and Amento
    J Inflamm (Lond)  2014;11:37
  5. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
    Authors: He Et al.
    FASEB J  2013;27:3446
  6. Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.
    Authors: Garção Et al.
    Br J Pharmacol  2013;169:1600
  7. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol  2012;86:10338
  8. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.
    Authors: Hua Et al.
    PLoS One  2011;6:e24947
  9. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
    Authors: Pedroza Et al.
    Mol Vis  2011;6:e22667
  10. Adenosine can mediate its actions through generation of reactive oxygen species.
    Authors: Gebremedhin Et al.
    J Cereb Blood Flow Metab  2010;30:1777
  11. Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
    Authors: Yu Et al.
    Am J Respir Crit Care Med  2009;297:L785
  12. Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
    Authors: Wolk Et al.
    PLoS One  2008;178:969
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