Catalog Number: 2752
Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Biological Activity
Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming and to 10 mM in DMSO with sonication
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Virginia Patent Foundation
Background References
  1. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
    Kim et al.
    J.Med.Chem., 2000;43:1165
  2. [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors.
    Ji et al.
    Biochem.Pharmacol., 2001;61:657
  3. Adenosine receptor activation ameliorates type I diabetes.
    Nemeth et al.
    FASEB J., 2007;21:2380
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