Catalog Number: 2752
Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Biological Activity
Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
Technical Data
  • M.Wt:
    486.52
  • Formula:
    C26H26N6O4
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming and to 10 mM in DMSO with sonication
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    264622-58-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Virginia Patent Foundation
Background References
  1. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
    Kim et al.
    J.Med.Chem., 2000;43:1165
  2. [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors.
    Ji et al.
    Biochem.Pharmacol., 2001;61:657
  3. Adenosine receptor activation ameliorates type I diabetes.
    Nemeth et al.
    FASEB J., 2007;21:2380
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 1754 include:

11 Citations: Showing 1 - 10
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  1. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.
    Authors: Asano
    Scientific Reports 2017;7:40214
  2. Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
    Authors: Ledderose Et al.
    Purinergic Signalling 2016;
  3. Anti-inflammatory effects of adenosine N1-oxide.
    Authors: Kohno Et al.
    Am J Physiol Lung Cell Mol Physiol 2015;12:2
  4. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
    Authors: Welihinda and Amento
    J Inflamm (Lond) 2014;11:37
  5. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
    Authors: He Et al.
    FASEB J 2013;27:3446
  6. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol 2012;86:10338
  7. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.
    Authors: Hua Et al.
    PLoS One 2011;6:e24947
  8. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
    Authors: Pedroza Et al.
    Mol Vis 2011;6:e22667
  9. Adenosine can mediate its actions through generation of reactive oxygen species.
    Authors: Gebremedhin Et al.
    J Cereb Blood Flow Metab 2010;30:1777
  10. Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
    Authors: Yu Et al.
    Am J Respir Crit Care Med 2009;297:L785
  11. Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
    Authors: Wolk Et al.
    PLoS One 2008;178:969
Expand to show all 11 Citations

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