Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Biological ActivityMRS 1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
Kim et al.
[3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors.
Ji et al.
Adenosine receptor activation ameliorates type I diabetes.
Nemeth et al.
FASEB J., 2007;21:2380
Citations for MRS 1754
The citations listed below are publications that use Tocris products. Selected citations for MRS 1754 include:
16 Citations: Showing 1 - 10
Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
Authors: Liu Et al.
Brain Res 2018;1700:47
Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.
Scientific Reports 2017;7:40214
An Adenosine Receptor for Olfaction in Fish.
Authors: Wakisaka Et al.
Curr Biol 2017;27:1437
Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
Authors: Ledderose Et al.
Purinergic Signalling 2016;
Anti-inflammatory effects of adenosine N1-oxide.
Authors: Kohno Et al.
Am J Physiol Lung Cell Mol Physiol 2015;12:2
Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain.
Authors: Lemos Et al.
Purinergic Signal 2015;11:561
Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
Authors: Welihinda and Amento
J Inflamm (Lond) 2014;11:37
Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
Authors: He Et al.
FASEB J 2013;27:3446
Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Authors: Garção Et al.
Br J Pharmacol 2013;169:1600
Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
Authors: Kan Et al.
J Virol 2012;86:10338
IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.
Authors: Hua Et al.
PLoS One 2011;6:e24947
Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
Authors: Pedroza Et al.
Mol Vis 2011;6:e22667
Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection.
Authors: Zhan Et al.
Am J Physiol Heart Circ Physiol 2011;301:H1183
Adenosine can mediate its actions through generation of reactive oxygen species.
Authors: Gebremedhin Et al.
J Cereb Blood Flow Metab 2010;30:1777
Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
Authors: Yu Et al.
Am J Respir Crit Care Med 2009;297:L785
Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
Authors: Wolk Et al.
PLoS One 2008;178:969
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for MRS 1754
There are currently no reviews for this product. Be the first to review MRS 1754 and earn rewards!
Have you used MRS 1754?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image