MRS 1754

Key Product Details

Product Description

MRS 1754 is a selective adenosine A_2B receptor antagonist (K_i values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA_2B, rA₁, hA₁, hA_2A, hA₃ and rA_2A receptors respectively).

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Product Specifications for MRS 1754

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRS 1754

The following data is based on the product molecular weight 486.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	41.11 mL	205.54 mL	411.08 mL
0.25 mM	8.22 mL	41.11 mL	82.22 mL
0.5 mM	4.11 mL	20.55 mL	41.11 mL
2.5 mM	0.82 mL	4.11 mL	8.22 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 82 publications citing the usage of this product.

• Ji [³H]MRS 1754, a selective antagonist radioligand for A_2B adenosine receptors. Biochem.Pharmacol. 2001 PMID: 11266650
• Nemeth Adenosine receptor activation ameliorates type I diabetes. FASEB J.
• Kim Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A_2B adenosine receptors. J.Med.Chem. 2000 PMID: 10737749

Product Documents for MRS 1754