MRS 5698
Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Purity: ≥96%
Biological Activity
MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Little et al.
Brain, 2015;138:28 -
Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.
Tosh et al.
J.Med.Chem., 2012;55:4847 -
Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain.
Tosh et al.
Purinergic Signal., 2015;11:371
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Citation for MRS 5698
The citations listed below are publications that use Tocris products. Selected citations for MRS 5698 include:
1 Citation: Showing 1 - 1
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Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells
Authors: Fong Et al.
Natural Product Communications 2019;14:1
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