Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Biological ActivityMRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Little et al.
Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.
Tosh et al.
Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain.
Tosh et al.
Purinergic Signal., 2015;11:371
Citation for MRS 5698
The citations listed below are publications that use Tocris products. Selected citations for MRS 5698 include:
1 Citation: Showing 1 - 1
Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells
Authors: Fong Et al.
Natural Product Communications 2019;14:1
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