MRT 68601 hydrochloride

Key Product Details

Product Description

MRT 68601 hydrochloride is a potent TBK1 (TANK-binding kinase-1) inhibitor (IC₅₀ = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.

Product Specifications for MRT 68601 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRT 68601 hydrochloride

The following data is based on the product molecular weight 487.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.27 mL	20.53 mL
5 mM	0.41 mL	2.05 mL	4.11 mL
10 mM	0.21 mL	1.03 mL	2.05 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• McIver Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 2012 PMID: 23099093
• Newman TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 2012 PMID: 23209807

Product Documents for MRT 68601 hydrochloride