Potent and selective type I PRMT inhibitor (IC50
values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro
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This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary
on the SGC website.
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases.
Eram et al.
ACS Chem.Biol., 2016;11:772