MS 023 dihydrochloride

Tocris Bioscience | Catalog # 5713

Potent and selective type I PRMT inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective type I PRMT inhibitor
View all Protein Arginine Methyltransferase Inhibitors »

Product Description

MS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro. Also inhibits and reduces TGF-β-activated kinase 1 expression and protein levels.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.

Product Specifications for MS 023 dihydrochloride

Molecular Weight

360.32

Formula

C17H25N3O.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride

CAS Number

1992047-64-9

PubChem ID

121513886

InChI Key

HCNXCUFNZWGILO-UHFFFAOYSA-N

SMILES

CC(C)OC1=CC=C(C2=CNC=C2CN(CCN)C)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.03 100
DMSO 36.03 100

Preparing Stock Solutions for MS 023 dihydrochloride

The following data is based on the product molecular weight 360.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.88 mL 27.75 mL
5 mM 0.56 mL 2.78 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MS 023 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 023 dihydrochloride

For research use only

Related Research Areas

Epigenetics

Citations for MS 023 dihydrochloride

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