MS 023 dihydrochloride
Chemical Name: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride
Biological ActivityMS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro. Also inhibits and reduces TGF-β-activated kinase 1 expression and protein levels.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Scheer et al.
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases.
Eram et al.
ACS Chem.Biol., 2016;11:772
Citations for MS 023 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for MS 023 dihydrochloride include:
3 Citations: Showing 1 - 3
A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer.
Authors: Tang Et al.
Cell Rep. 2022;38:110417
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
Authors: Lu Et al.
The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer.
Authors: Choucair Et al.
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