MS 147

Tocris Bioscience | Catalog # 8077

PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B
Tocris Bioscience

Key Product Details

Description

PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B
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Product Description

MS 147 is a polycomb repressive complex 1 (PRC1) Degrader (PROTAC®) (Kd values are 450 nM and 3 μM for VHL and EED, respectively). Comprises an EED binder (EED 226, Cat. No. 7762) joined by a linker to a VHL E3 ligase ligand. MS 147 preferentially degrades BMI1 and RING1B and reduces H2AK119ub in K562 cells. Inhibits proliferation in cancer cell lines that are insensitive to EZH2 knockout or EED/PRC2 Degraders.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Important Information

This product is sold as an HCl salt. The stoichiometry of the salt and hydration levels vary from batch to batch. It is sold in gross weight and the batch specific Molecular Weight is available on the Certificate of Analysis.

Product Specifications for MS 147

Formula

C54H70N12O6S.xHCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

InChI Key

WZUKNVLQEQHTMY-RTJWYONCSA-N

SMILES

CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCCNC(CCCCN4CCN(C5=CC=C(C6=CN=C(NCC7=CC=CO7)N8C6=NN=C8)C=C5)CC4)=O)=O)C(C)(C)C)=O)=O)C=C2)SC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 50mg/ml in DMSO

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Background References

References are publications that support the biological activity of the product.

Product Documents for MS 147

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 147

For research use only

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