MS 154N

Tocris Bioscience | Catalog # 7396

Negative control for MS 154 (Cat No. 7395)
Tocris Bioscience

Key Product Details

Description

Negative control for MS 154 (Cat No. 7395)
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Product Description

MS 154N is a negative control for MS 154 (Cat No. 7395). The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kd values are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Product Specifications for MS 154N

Molecular Weight

915.46

Formula

C47H56ClFN8O8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide

CAS Number

2675490-97-6

PubChem ID

155515813

InChI Key

XFUDPXQGWCYCCR-UHFFFAOYSA-N

SMILES

COC1=CC2=C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)C=C1OCCCN4CCN(CC4)CCC(NCCCCCCCCOC5=C6C(N(C(C6=CC=C5)=O)C7CCC(N(C)C7=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 91.55 100

Preparing Stock Solutions for MS 154N

The following data is based on the product molecular weight 915.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.22 mL 1.09 mL 2.18 mL
10 mM 0.11 mL 0.55 mL 1.09 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Product Documents for MS 154N

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 154N

For research use only

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