Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Biological ActivityMS 154N is a negative control for MS 154 (Cat No. 7395). The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kd values are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders.
Cheng et al.
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