MS 159

Key Product Details

Product Description

MS 159 is a nuclear receptor binding SET structural domain protein 2 (NSD2) Degrader (DC₅₀ = 5.2 μM, D_max = >82%). Also degrades IKZF3 and IKZF1. Comprises an NSD2 binding moiety joined by a linker to a cereblon E3 ligase ligand. Inhibits proliferation of KMS11 and H929 tumor cells. Bioavailable in vivo.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for MS 159

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MS 159

The following data is based on the product molecular weight 828.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.41 mL	12.07 mL	24.13 mL
2.5 mM	0.48 mL	2.41 mL	4.83 mL
5 mM	0.24 mL	1.21 mL	2.41 mL
25 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Meng Discovery of a first-in-class degrader for nuclear receptor binding SET domain protein 2 (NSD2) and Ikaros/Aiolos. J.Med.Chem. 2022 PMID: 35895319

Product Documents for MS 159