MS 245 oxalate

Key Product Details

Product Description

MS 245 oxalate is a high affinity 5-HT₆ antagonist (K_i = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.

Product Specifications for MS 245 oxalate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MS 245 oxalate

The following data is based on the product molecular weight 448.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.46 mL	22.30 mL	44.59 mL
2.5 mM	0.89 mL	4.46 mL	8.92 mL
5 mM	0.45 mL	2.23 mL	4.46 mL
25 mM	0.09 mL	0.45 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Young Effect of the 5-HT₆ serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 2006 PMID: 16950502
• Dukat Binding of serotonin and N₁-benzenesulfonyltryptamine-related analogs at human 5-HT₆ serotonin receptors: receptor modeling studies. J.Med.Chem. 2008 PMID: 18201064
• Nirogi Novel and potent 5-piperazinyl methyl-N₁-aryl sulfonyl indole derivatives as 5-HT₆ receptor ligands. ACS Med.Chem.Lett.
• Glennon 2-substituted tryptamines: agents with selectivity for 5-HT₆ serotonin receptors. J.Med.Chem. 2000 PMID: 10715164

Product Documents for MS 245 oxalate