MS 245 oxalate

Catalog # Availability Size / Price Qty
4208/10
4208/50
5-HT6 Receptor Antagonists Small Molecule
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Description: High affinity 5-HT6 antagonist

Chemical Name: 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate

Purity: ≥99%

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Biological Activity

High affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.

Technical Data

M.Wt:
448.49
Formula:
C19H22N2O3S.C2H2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
275363-58-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine.
    Young et al.
    Pharmacol.Biochem.Behav., 2006;85:170
  2. 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors.
    Glennon et al.
    J.Med.Chem., 2000;43:1011
  3. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.
    Dukat et al.
    J.Med.Chem., 2008;51:603
  4. Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands.
    Nirogi et al.
    ACS Med.Chem.Lett., 2010;1:340

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