MS 245 oxalate
Chemical Name: 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate
Biological ActivityHigh affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine.
Young et al.
2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors.
Glennon et al.
Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.
Dukat et al.
Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands.
Nirogi et al.
ACS Med.Chem.Lett., 2010;1:340
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