MS 6105

Tocris Bioscience | Catalog # 8073

Potent lactate dehydrogenase Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent lactate dehydrogenase Degrader (PROTAC®)
View all Active Degraders »

Product Description

MS 6105 is a potent and selective lactate dehydrogenase (LDH) Degrader (PROTAC®; for LDHA and LDHB respectively, DC50 values are 38 nM and 74 nM; Dmax is 93% and 86%). Comprises an LDH inhibitor warhead connected by a linker to a VHL ligand. Suppresses growth of several pancreatic cancer cell lines (IC50 range is 12.2 μM - 16.1 μM). Bioavailable in vivo.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for MS 6105

Molecular Weight

1228.60

Formula

C65H81N9O9S3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid

CAS Number

2891709-58-1

PubChem ID

166642429

InChI Key

APEYSKGQWJKJAZ-LCLGPXMOSA-N

SMILES

O=C([C@@H](NC(CCCCCCCCCCCC(NCCCCC#CC1=CC=CC(C2=NN(C(CC3CC3)=C2CC4=CC=C(S(N)(=O)=O)C=C4)C5=NC(C(O)=O)=CS5)=C1)=O)=O)C(C)(C)C)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 122.86 100

Preparing Stock Solutions for MS 6105

The following data is based on the product molecular weight 1228.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.81 mL 4.07 mL 8.14 mL
5 mM 0.16 mL 0.81 mL 1.63 mL
10 mM 0.08 mL 0.41 mL 0.81 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for MS 6105

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 6105

For research use only

Customer Reviews for MS 6105

There are currently no reviews for this product. Be the first to review MS 6105 and earn rewards!

Have you used MS 6105?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card