Chemical Name: 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
Biological ActivityMSA 2 is a non-nucleotide STING agonist (EC50 values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
An orally available non-nucleotide STING agonist with antitumor activity.
Pan et al.
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