MU 1700 trihydrochloride

Key Product Details

Product Description

MU 1700 trihydrochloride is a potent and selective ALK2 and ALK1 inhibitor (IC₅₀ values are 6 nM and 13 nM, respectively in biochemical assays). It is also a potent ALK6 inhibitor (IC₅₀ = 41 nM). It shows selectivity for ALK over >360 other kinases. It shows favorable pharmacokinetic for in vivo use. MU 1700 trihydrochloride is orally bioavailable. It is cell membrane permeable and brain penetrant.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1700 probe summary on the SGC website.

Product Specifications for MU 1700 trihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MU 1700 trihydrochloride

The following data is based on the product molecular weight 515.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.88 mL	19.39 mL	38.77 mL
2.5 mM	0.78 mL	3.88 mL	7.75 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Němec Discovery of two highly selective structurally orthogonal chemical probes for activin receptor-like kinases 1 and 2. J.Med.Chem. 2024 PMID: 39023313

Product Documents for MU 1700 trihydrochloride