Muristerone A

Catalog # Availability Size / Price Qty
Muristerone A | CAS No. 38778-30-2 | Additional Bcl-2 Family Compounds
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Description: Stimulates Bcl-XL mRNA transcription; antiapoptotic

Chemical Name: (2β,3β,5β,11α,22R)-2,3,5,11,14,20,22-Heptahydroxycholest-7-en-6-one

Purity: ≥97%

Product Details

Biological Activity

Muristerone A is an ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

Technical Data

Soluble in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering.
    Patrick et al.
    Tissue Eng., 2001;7:303
  2. Ecdysone-inducible gene expression in mammalian cells and transgenic mice.
    No et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:3346
  3. Agonists of an ecdysone-inducible mammalian expression system inhibit Fas-ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.
    Bosser and Zornig
    Cell Death Diff., 2005;13:189

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