N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Catalog # Availability Size / Price Qty
1927/1
Cat.No. 1927 - N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu | Ac-pTyr-Glu-Glu-Ile-Glu | CAS No. 159439-02-8
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Description: Phosphopeptide ligand for src SH2 domain

Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid

Product Details
Reviews

Biological Activity

Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.

Technical Data

M.Wt:
803.71
Formula:
C32H46N5O17P
Sequence:
YEEIE

(Modifications: Tyr-1 = pTyr with C-terminal Ac)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
159439-02-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.
    Gilmer et al.
    J.Biol.Chem., 1994;269:31711
  2. Potent dipeptide inhibitors of the pp60c-src SH2 domain.
    Pacofsky et al.
    J.Med.Chem., 1998;41:1894
  3. Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains.
    Park et al.
    Bioorg.Med.Chem.Lett., 2002;12:2711

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