Catalog Number: 1927
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Biological Activity
Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Tyr-1 = pTyr with C-terminal Ac)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.
    Gilmer et al.
    J.Biol.Chem., 1994;269:31711
  2. Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains.
    Park et al.
    Bioorg.Med.Chem.Lett., 2002;12:2711
  3. Potent dipeptide inhibitors of the pp60c-src SH2 domain.
    Pacofsky et al.
    J.Med.Chem., 1998;41:1894
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