Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Biological ActivityN-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
(Modifications: Tyr-1 = pTyr with C-terminal Ac)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.
Gilmer et al.
Potent dipeptide inhibitors of the pp60c-src SH2 domain.
Pacofsky et al.
Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains.
Park et al.
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