Endogenous anandamide-like compound. Lacks affinity for CB1
> 10 μ
M), VR1 receptors (EC50
> 10 μ
M) and anandamide transporters (IC50
> 50 μ
M) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Oxidative metabolism of anandamide.
Burnstein et al.
Prostaglandins Other Lipid Mediat., 2000;61:29
Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
Edington et al.
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
Huang et al.
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.
Sheskin et al.