N-Arachidonylglycine
Tocris Bioscience | Catalog # 1445
Key Product Details
Description
Alternative Names
Product Description
N-Arachidonylglycine is a GPR18 agonist (EC50 = 44.5 nM). Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki > 10 μM), VR1 receptors (EC50 > 10 μM) and anandamide transporters (IC50 > 50 μM) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.
Product Specifications for N-Arachidonylglycine
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Ethanol | 36.15 | 100 |
Preparing Stock Solutions for N-Arachidonylglycine
The following data is based on the product molecular weight 361.52.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.83 mL | 27.66 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Background References
References are publications that support the biological activity of the product.
- McHugh Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells Br.J.Pharmacol. 2012 PMID: 21595653
- Kohno Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun. 2006 PMID: 16844083
- Sheskin Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J.Med.Chem. 1997 PMID: 9057852
- Huang Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J.Biol.Chem. 2001 PMID: 11518719
- Edington Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J.Biol.Chem. 2009 PMID: 19875446
- Burnstein Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 2000 PMID: 10785540
Product Documents for N-Arachidonylglycine
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for N-Arachidonylglycine
For research use only
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Species: HumanVerified Customer | Posted 08/29/2019Product used to significantly inhibit TNF alpha and IFN gamma production.It shows potential as a therapeutic treatment for chronic inflammation and interactive effects on immune system.
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